Clinical trials are the “gold standard” for evaluating which treatments work best in medicine. However the results of these trials are still routinely left unreported. This undermines the ability of doctors, researchers and patients to make informed decisions about which treatments work best.

Our TrialsTracker project has produced a wide range of tools and initiatives to monitor and improve clinical trial reporting. Our live audit tools have received extensive global media coverage from the FT, BBC, Telegraph, Times, Nature, Le Figaro, CBC, La Sante, and more. Data on our FDAAA TrialsTracker updates every working day: it monitors compliance with the FDA Amendment Act 2007, a US law requiring sponsors to report results onto within 12 months of completion. Our EU TrialsTracker monitors compliance with EU guidelines on the EU trials registry. Our original prototype TrialsTracker remains online for interest.

We have also evaluated the quality of trial reporting, and trial reporting policies among commercial and non-commercial funders of clinical research. Our COMPare project wrote correction letters to academic journals when they published trial reports that breached CONSORT guidance and misreported their prespecified outcomes. We also work on other research integrity issues including conflicts of interests and retracted papers.

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