1. Association between warfarin and COVID-19-related outcomes compared with direct oral anticoagulants

    This paper conducted a population-based cohort study investigating the association between warfarin and COVID-19 outcomes compared with direct oral anticoagulants (DOACs).

    Status
    Published

    Categories

    • OpenSAFELY
  2. Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England

    This paper aims to describe the severity of the alpha variant in terms of the pathway of disease from testing positive to hospital admission and death.

    Status
    Published

    Categories

    • OpenSAFELY
  3. Risks of covid-19 hospital admission and death for people with learning disability

    Working on behalf of NHS England, this paper used the OpenSAFELY platform to assess the association between learning disability and risk of hospitalisation and mortality from COVID-19 in England among adults and children.

    Status
    Published

    Categories

    • OpenSAFELY
  4. Factors associated with deaths due to COVID-19 versus other causes

    We aimed to investigate how specific factors are differentially associated with COVID-19 mortality as compared to mortality from causes other than COVID-19.

    Status
    Published

    Categories

    • OpenSAFELY
  5. Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England

    Working on behalf of NHS England, this paper used the OpenSAFELY platform to quantify ethnic differences in SARS-CoV-2 infection and COVID-19 outcomes during the first and second waves of the COVID-19 pandemic in England.

    Status
    Published

    Categories

    • OpenSAFELY
  6. Identifying Care Home Residents in Electronic Health Records

    This short data report describes the partial overlap between three methods for identifying care home residents in EHR, and provides detailed instructions for how to implement these in OpenSAFELY-TPP to support research into the impact of the COVID-19 pandemic on care home residents.

    Status
    Published

    Categories

    • OpenSAFELY
  7. Association between living with children and outcomes from covid-19

    Working on behalf of NHS England, this paper used the OpenSAFELY platform to investigate whether risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and outcomes of coronavirus disease 2019 (covid-19) differed between adults living with and without children during the first two waves of the UK pandemic.

    Status
    Published

    Categories

    • OpenSAFELY
  8. Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7

    Working on behalf of NHS England, this paper uses the OpenSAFELY platform to estimate the risk of death following confirmation of SARS-CoV-2 infection in England, comparing infection with VOC to non-VOC, after accounting for demographic factors and comorbidities

    Status
    Published

    Categories

    • OpenSAFELY
  9. Changes in the rate of cardiometabolic and pulmonary events during the COVID-19 pandemic

    Working on behalf of NHS England, this study used the OpenSAFELY platform to describe the overall rate of various key clinical events over time, and their relationship with COVID-19.

    Status
    Preprint

    Categories

    • OpenSAFELY
  10. Short report: Ethnicity and COVID-19 death in the early part of the COVID-19 second wave in England

    This short data report investigates whether there were ethic inequalities in COVID-19 death in the second wave in England.

    Status
    Preprint

    Categories

    • OpenSAFELY
  11. Use of non-steroidal anti-inflammatory drugs and risk of death from COVID-19

    Working on behalf of NHS England, this paper used the OpenSAFELY platform to assess the association between routinely prescribed non-steroidal anti-inflammatory drugs (NSAIDs) and deaths from COVID-19.

    Status
    Published

    Categories

    • OpenSAFELY
  12. HIV infection and COVID-19 death

    Working on behalf of NHS England, this paper used the OpenSAFELY platform to investigate the association between HIV infection and COVID-19 mortality.

    Status
    Published

    Categories

    • OpenSAFELY
  13. Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality

    Working on behalf of NHS England, this paper used the OpenSAFELY platform to investigate the effectiveness of hydroxychloroquine for prevention, as opposed to treatment, of COVID-19 mortality. We found no evidence of benefit or harm after adjusting for important differences between people with the same health conditions prescribed hydroxychloroquine or not.

    Status
    Published

    Categories

    • OpenSAFELY
  14. Impact of Electronic Health Record Interface Design on Unsafe Prescribing of Ciclosporin, Tacrolimus, and Diltiazem: Cohort Study in English National Health Service Primary Care

    JMIR EHR design paper

    Categories

    • OpenPrescribing
    • Policy Insights
  15. Comparison of different risk prediction modelling approaches for COVID-19 related death using the OpenSAFELY platform

    This protocol reports details of a planned study to explore the extent to which incorporating time-varying measures of infection burden over time improves the quality of risk prediction models for COVID-19 death in a large population of adult patients in England.

    Status
    Preprint

    Categories

    • OpenSAFELY
  16. Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids

    Working on behalf of NHS England, this paper used the OpenSAFELY platform to investigate the association between ICS and COVID-19-related death among people with COPD or asthma using linked electronic health records (EHRs) in England, UK.

    Status
    Published

    Categories

    • OpenSAFELY
  17. How we learnt to stop worrying and love web scraping

    Nature web scraping article

    Categories

    • Open Working
    • Research Integrity
  18. Suboptimal prescribing behaviour associated with clinical software design features: a retrospective cohort study in English NHS primary care

    EHR design paper

    Categories

    • OpenPrescribing
    • Research Integrity