1. Eleven key measures for monitoring general practice clinical activity during COVID-19: A retrospective cohort study using 48 million adults’ primary care records in England through OpenSAFELY

    This paper presents an important effort to develop an open-source software framework for monitoring trends and variations in healthcare over time in England. They demonstrate a compelling example of how this system can track key healthcare indicators over the course of the COVID-19 pandemic.

    Categories

    • OpenSAFELY
  2. Evaluation of the impact of COVID-19 pandemic on hospital admission related to common infections

    We studied the changes in hospital admission rates for common infections during the Covid-19 pandemic, for those having and having not received antibiotic prescriptions in primary care

    Status
    Preprint

    Categories

    • OpenSAFELY
  3. Repeated antibiotic exposure and risk of hospitalisation and death following COVID-19 infection (OpenSAFELY): a matched case–control study

    We examined whether prior frequent antibiotic exposure is associated with severe COVID-19 outcomes.

    Categories

    • OpenSAFELY
  4. Data-driven identification of potentially successful intervention implementations: a proof of concept using five years of opioid prescribing data from over 7000 practices in England

    By applying one of our existing analysis tools to a national dataset, we were able to rank NHS organisations by reduction in opioid prescribing rates. Highly ranked organisations are candidates for further qualitative research into intervention design and implementation.

    Status
    Preprint

    Categories

    • OpenPrescribing
  5. DMARD monitoring during the COVID-19 pandemic

    This study investigated whether disease-modifying anti-rheumatic drug (DMARD) safety monitoring was affected during the COVID-19 pandemic, with additional focus on effects within key health inequality groups.

    Categories

    • OpenSAFELY
  6. Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics

    This study aimed to implement complex, PINCER (pharmacist led information technology intervention) prescribing indicators, on a national scale with general practice data to describe the impact of the covid-19 pandemic on safe prescribing.

    Categories

    • OpenSAFELY
  7. Impact of COVID-19 on broad-spectrum antibiotic prescribing for common infections in primary care in England: a time-series analyses using OpenSAFELY and effects of predictors including deprivation

    Impact of COVID-19 on broad-spectrum antibiotic prescribing for common infections in primary care in England: a time-series analyses using OpenSAFELY and effects of predictors including deprivation

    Categories

    • OpenSAFELY
  8. The impact of COVID-19 on antibiotic prescribing in primary care in England: Evaluation and risk prediction of appropriateness of type and repeat prescribing

    This study predicted risk factors for potentially inappropriate prescribing in primary care and how this changed during the Covid-19 pandemic

    Categories

    • OpenSAFELY
  9. Challenges in Estimating the Effectiveness of COVID-19 Vaccination Using Observational Data

    This paper discusses the challenges in estimating vaccine effectiveness using observational data, and describes two approaches that help to overcome these challenges.

    Categories

    • OpenSAFELY
  10. Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022: a retrospective cohort study using the OpenSAFELY platform

    This study aimed to describe the burden of COVID-19-related mortality in population subgroups and how this has changed over successive waves of the pandemic, and report trends in absolute and relative COVID-19-related mortality risks across clinical and demographic population subgroups from 2020 to 2022.

    Categories

    • OpenSAFELY
  11. Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England

    Data-driven approaches have the potential to overcome existing biases with regard to the planning and execution of audits, interventions, and policy making within NHS organizations, potentially revealing new targets for improved health care service delivery.

    Categories

    • OpenPrescribing
  12. Comparative effectiveness of BNT162b2 versus mRNA-1273 covid-19 vaccine boosting in England: matched cohort study in OpenSAFELY-TPP

    A comparison of the Pfizer and Moderna vaccines for protecting against Covid-19 during the first booster programme in England

    Categories

    • OpenSAFELY
  13. First dose COVID-19 vaccine coverage amongst adolescents and children in England: an analysis of 3.21 million patients' primary care records in situ using OpenSAFELY

    Describing trends and variation in vaccine coverage in different clinical and demographic groups amongst adolescents and children in England

    Categories

    • OpenSAFELY
  14. Identifying Patterns of Clinical Interest in Clinicians' Treatment Preferences: Hypothesis-free Data Science Approach to Prioritizing Prescribing Outliers for Clinical Review

    A new method for prioritizing prescribing outliers for clinical review with discussion of two illustrative examples of anti-psychotics

    Categories

    • OpenPrescribing
  15. OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19

    Working on behalf of NHS England, this study used the OpenSAFELY platform to describe the volume and variation of coded clinical activity in general practice between January 2019 and September 2020, taking respiratory disease and laboratory procedures as examples.

    Status
    Published

    Categories

    • OpenSAFELY
  16. Trends and clinical characteristics of COVID-19 vaccine recipients

    Vaccine coverage and time trends across a range of demographic and fine-grained clinical subgroups in eight Joint Committee on Vaccination and Immunisation (JCVI) priority cohorts.

    Status
    Published

    Categories

    • OpenSAFELY
  17. Impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic

    This paper describes which people were switched from warfarin to DOACs during the COVID-19 pandemic following an update in national guidance

    Status
    Published

    Categories

    • OpenSAFELY
  18. Clinical coding of long COVID in English primary care

    Working on behalf of NHS England, this paper used the OpenSAFELY platform to measure the proportion of people with a recorded code for long COVID, overall and by demographic factors, electronic health record software system, and week.

    Status
    Published

    Categories

    • OpenSAFELY