Papers

Showing 155 published or preprint papers authored by the Bennett Institute.

  1. Incidence and treatment of group A streptococcal infections during covid-19 pandemic and 2022 outbreak

    Investigation of the effect of the covid-19 pandemic on the number of patients with group A streptococcal infections and related antibiotic prescriptions

    Status: Published

    Categories

    • OpenSAFELY
  2. OpenSAFELY: Effectiveness of COVID-19 vaccination in children and adolescents

    We conducted a matched sequential trials observational study to assess the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination in children and adolescents in England.

    Status: Preprint

    Categories

    • OpenSAFELY
  3. Clinical coding of long COVID in primary care 2020–2023 in a cohort of 19 million adults

    Incidence and differences in demographic and clinical characteristics in recorded long COVID in primary care records in England.

    Status: Published

    Categories

    • OpenSAFELY
  4. Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations

    To examine the impact of the pandemic on deprivation-related inequalities in hospitalisations for CVD conditions in Denmark and England between March 2018 and December 2021.

    Status: Preprint

    Categories

    • OpenSAFELY
  5. The impact of the COVID-19 pandemic on Antidepressant Prescribing with a focus on people with learning disability and autism

    COVID-19 lockdowns led to increased reports of depressive symptoms in the general population and impacted the health and social care services of people with learning disability and autism. We explored whether the COVID-19 pandemic had an impact on antidepressant prescribing trends within these and the general population.

    Status: Preprint

    Categories

    • OpenSAFELY
  6. Impact of long COVID on health-related quality-of-life: an OpenSAFELY population cohort study using patient-reported outcome measures (OpenPROMPT)

    We aimed to evaluate and estimate the differences in health impacts of long COVID across sociodemographic categories and quantify this in Quality-Adjusted Life-Years (QALYs), widely used measures across health systems.

    Status: Published

    Categories

    • OpenSAFELY
  7. Identification of patients undergoing chronic kidney replacement therapy in primary and secondary care data

    Identification of people receiving chronic kidney replacement therapy using primary and secondary care records compared with gold standard registry data.

    Status: Published

    Categories

    • OpenSAFELY
  8. The impact of COVID-19 on azathioprine, leflunomide and methotrexate monitoring, and factors associated with change in monitoring rate

    This study investigated whether disease-modifying anti-rheumatic drug (DMARD) safety monitoring was affected during the COVID-19 pandemic, with additional focus on effects within key health inequality groups.

    Status: Published

    Categories

    • OpenSAFELY
  9. The impact of COVID-19 on medication reviews in English primary care

    This study investigated whether the rate of medication reviews in primary care were affected during the COVID-19 pandemic, with breakdown by regional, clinical and demographic subgroups.

    Status: Published

    Categories

    • OpenSAFELY
  10. Comparative safety and effectiveness of Pfizer BA.4-5 versus Sanofi during the spring 2023 COVID-19 booster vaccination programme in England

    A comparison of the Pfizer BA.4-5 and Sanofi vaccines for protecting against Covid-19 during Spring 2023 booster programme in England

    Status: Preprint

    Categories

    • OpenSAFELY
  11. Impact of vaccination on the association of COVID-19 with cardiovascular diseases

    We quantified associations between COVID-19 diagnosis and cardiovascular diseases in different vaccination and variant eras using linked electronic health records for ~40% of the English population.

    Status: Published

    Categories

    • OpenSAFELY
  12. During the COVID-19 pandemic 20 000 prostate cancer diagnoses were missed in England

    This study investigated the effect of the COVID-19 pandemic on prostate cancer incidence, prevalence, and mortality in England. The pandemic led to 20 000 missed prostate cancer diagnoses in England alone.

    Status: Published

    Categories

    • OpenSAFELY
  13. Changes in opioid prescribing during the COVID-19 pandemic in England

    This study described changes in prevalent and new opioid prescribing during the COVID-19 pandemic, overall, among people in care homes, and stratified by demographics.

    Status: Preprint

    Categories

    • OpenSAFELY
  14. The safety of antivirals and neutralising monoclonal antibodies used in prehospital treatment of Covid-19

    This proof-of-principle pharmacovigilance study used Electronic Health Record (EHR) data to examine the safety of sotrovimab, paxlovid and molnupiravir in prehospital treatment of Covid-19

    Status: Preprint

    Categories

    • OpenSAFELY
  15. Measuring BMI in 22 million patients in England

    This study describes the use of four derivations of BMI in OpenSAFELY.

    Status: Published

    Categories

    • OpenSAFELY
  16. Weight trends amongst adults with diabetes or hypertension during the COVID-19 pandemic

    Amongst adults living in England with T2D and/or hypertension, rapid pandemic weight gain was more common amongst females, younger adults, those living in more deprived areas, and those with mental health conditions.

    Status: Published

    Categories

    • OpenSAFELY
  17. Safety of direct-acting oral anticoagulant (DOAC) prescribing

    This study aimed to identify the proportion of those prescribed a DOAC with recorded: weight, estimated Glomerular Filtration Rate (eGFR), creatinine, creatinine clearance (CrCl) and atrial fibrillation (AF). In those with recorded AF and CrCl prescribed the study aimed to identify the proportion with a recommended DOAC dose.

    Status: Published

    Categories

    • OpenSAFELY
  18. OpenSAFELY: a platform for analysing electronic health records designed for reproducible research

    This paper describes OpenSAFELY's reproducibility-by-design approach in detail.

    Status: Published

    Categories

    • OpenSAFELY