Papers
Showing 154 published or preprint papers authored by the Bennett Institute.
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Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients’ records at source using OpenSAFELY
We describe the completeness and consistency of primary care ethnicity recording in the OpenSAFELY-TPP database, containing linked primary care and hospital records in >25 million patients in England. We also compared the ethnic breakdown in OpenSAFELY-TPP with that of the 2021 UK census.
Status: Published
Categories
- OpenSAFELY
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Changes in sick notes associated with COVID-19 from 2020 to 2022: a cohort study in 24 million primary care patients in OpenSAFELY-TPP
This study quantified the sick note rate in people with documented SARS-CoV-2 infection or COVID-19 diagnosis in 2020, 2021 and 2022 overall, by demographics, and by time since diagnosis. We also used adjusted Cox regression to compare the sick note rate to the general population.
Status: Published
Categories
- OpenSAFELY
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Effectiveness of mRNA COVID-19 Vaccines as First Booster Doses in England
We estimate the effectiveness of boosting with BNT162b2 or mRNA-1273 COVID-19 vaccines compared with no boosting in eligible adults who had received two primary course vaccine doses in England.
Status: Published
Categories
- OpenSAFELY
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Changes in opioid prescribing during the COVID-19 pandemic in England
This study described changes in prevalent and new opioid prescribing during the COVID-19 pandemic, overall, among people in care homes, and stratified by demographics.
Status: Published
Categories
- OpenSAFELY
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Data-Driven Identification of Potentially Successful Intervention Implementations Using 5 Years of Opioid Prescribing Data
By applying one of our existing analysis tools to a national dataset, we were able to rank NHS organisations by reduction in opioid prescribing rates. Highly ranked organisations are candidates for further qualitative research into intervention design and implementation.
Status: Published
Categories
- OpenPrescribing
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Incidence and treatment of group A streptococcal infections during covid-19 pandemic and 2022 outbreak
Investigation of the effect of the covid-19 pandemic on the number of patients with group A streptococcal infections and related antibiotic prescriptions
Status: Published
Categories
- OpenSAFELY
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OpenSAFELY: Effectiveness of COVID-19 vaccination in children and adolescents
We conducted a matched sequential trials observational study to assess the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination in children and adolescents in England.
Status: Preprint
Categories
- OpenSAFELY
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Clinical coding of long COVID in primary care 2020–2023 in a cohort of 19 million adults
Incidence and differences in demographic and clinical characteristics in recorded long COVID in primary care records in England.
Status: Published
Categories
- OpenSAFELY
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Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations
To examine the impact of the pandemic on deprivation-related inequalities in hospitalisations for CVD conditions in Denmark and England between March 2018 and December 2021.
Status: Preprint
Categories
- OpenSAFELY
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The impact of the COVID-19 pandemic on Antidepressant Prescribing with a focus on people with learning disability and autism
COVID-19 lockdowns led to increased reports of depressive symptoms in the general population and impacted the health and social care services of people with learning disability and autism. We explored whether the COVID-19 pandemic had an impact on antidepressant prescribing trends within these and the general population.
Status: Preprint
Categories
- OpenSAFELY
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Impact of long COVID on health-related quality-of-life: an OpenSAFELY population cohort study using patient-reported outcome measures (OpenPROMPT)
We aimed to evaluate and estimate the differences in health impacts of long COVID across sociodemographic categories and quantify this in Quality-Adjusted Life-Years (QALYs), widely used measures across health systems.
Status: Published
Categories
- OpenSAFELY
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Identification of patients undergoing chronic kidney replacement therapy in primary and secondary care data
Identification of people receiving chronic kidney replacement therapy using primary and secondary care records compared with gold standard registry data.
Status: Published
Categories
- OpenSAFELY
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The impact of COVID-19 on azathioprine, leflunomide and methotrexate monitoring, and factors associated with change in monitoring rate
This study investigated whether disease-modifying anti-rheumatic drug (DMARD) safety monitoring was affected during the COVID-19 pandemic, with additional focus on effects within key health inequality groups.
Status: Published
Categories
- OpenSAFELY
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The impact of COVID-19 on medication reviews in English primary care
This study investigated whether the rate of medication reviews in primary care were affected during the COVID-19 pandemic, with breakdown by regional, clinical and demographic subgroups.
Status: Published
Categories
- OpenSAFELY
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Comparative safety and effectiveness of Pfizer BA.4-5 versus Sanofi during the spring 2023 COVID-19 booster vaccination programme in England
A comparison of the Pfizer BA.4-5 and Sanofi vaccines for protecting against Covid-19 during Spring 2023 booster programme in England
Status: Preprint
Categories
- OpenSAFELY
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Impact of vaccination on the association of COVID-19 with cardiovascular diseases
We quantified associations between COVID-19 diagnosis and cardiovascular diseases in different vaccination and variant eras using linked electronic health records for ~40% of the English population.
Status: Published
Categories
- OpenSAFELY
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During the COVID-19 pandemic 20 000 prostate cancer diagnoses were missed in England
This study investigated the effect of the COVID-19 pandemic on prostate cancer incidence, prevalence, and mortality in England. The pandemic led to 20 000 missed prostate cancer diagnoses in England alone.
Status: Published
Categories
- OpenSAFELY
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The safety of antivirals and neutralising monoclonal antibodies used in prehospital treatment of Covid-19
This proof-of-principle pharmacovigilance study used Electronic Health Record (EHR) data to examine the safety of sotrovimab, paxlovid and molnupiravir in prehospital treatment of Covid-19
Status: Preprint
Categories
- OpenSAFELY