Papers
Spotlight
Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics
Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022: a retrospective cohort study using the OpenSAFELY platform
Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England
OpenSAFELY
Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics
Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022: a retrospective cohort study using the OpenSAFELY platform
Comparative effectiveness of BNT162b2 versus mRNA-1273 covid-19 vaccine boosting in England: matched cohort study in OpenSAFELY-TPP
First dose COVID-19 vaccine coverage amongst adolescents and children in England: an analysis of 3.21 million patients' primary care records in situ using OpenSAFELY
[PRE-PRINT] Association between living with children and outcomes from COVID-19: an OpenSAFELY cohort study of 12 million adults in England
[PRE-PRINT] Study protocol: Comparison of different risk prediction modelling approaches for COVID-19 related death using the OpenSAFELY platform
Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform
(PRE-PRINT) Ethnic differences in COVID-19 infection, hospitalisation, and mortality: an OpenSAFELY analysis of 17 million adults in England
(PRE-PRINT) Hydroxychloroquine for prevention of COVID-19 mortality: a population-based cohort study
(PRE-PRINT) OpenSAFELY: Do adults prescribed Non-steroidal anti-inflammatory drugs have an increased risk of death from COVID-19?
(PRE-PRINT) HIV infection and COVID-19 death: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform
OpenPrescribing
Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England
Identifying Patterns of Clinical Interest in Clinicians' Treatment Preferences: Hypothesis-free Data Science Approach to Prioritizing Prescribing Outliers for Clinical Review
Impact of Electronic Health Record Interface Design on Unsafe Prescribing of Ciclosporin, Tacrolimus, and Diltiazem: Cohort Study in English National Health Service Primary Care
Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform
Suboptimal prescribing behaviour associated with clinical software design features: a retrospective cohort study in English NHS primary care
Prescription of suboptimal statin treatment regimens: a retrospective cohort study of trends and variation in English primary care
Trends and variation in unsafe prescribing of methotrexate: a cohort study in English NHS primary care.
Variation in responsiveness to warranted behaviour change among NHS clinicians: novel implementation of change detection methods in longitudinal prescribing data
Impact of Chief Medical Officer activity on prescribing of antibiotics in England: an interrupted time series analysis
Is Use of Homeopathy Associated With Poor Prescribing in English Primary Care? A Cross-Sectional Study
Do doctors in dispensing practices with a financial conflict of interest prescribe more expensive drugs? A cross-sectional analysis of English primary care prescribing data.
Measuring the Impact of an Open Web-Based Prescribing Data Analysis Service on Clinical Practice: Cohort Study on NHS England Data
Why did some practices not implement new antibiotic prescribing guidelines on urinary tract infection? A cohort study and survey in NHS England primary care
Opioid prescribing trends and geographical variation in England, 1998–2018: a retrospective database study
Six months on – NHS England needs to focus on dissemination, implementation and audit of its Low-Priority Initiative
Reply to Comment on 'Impact of NICE guidance on tamoxifen prescribing in England 2011–2017: an interrupted time series analysis'
Detecting Change in Comparison to Peers in NHS Prescribing Data: a Novel Application of Cumulative Sum Methodology
The clinician impact and financial cost to the NHS of litigation over pregabalin: a cohort study in English primary care
Trends and variation in prescribing of low-priority treatments identified by NHS England: a cross-sectional study and interactive data tool in English primary care
Time trends and geographical variation in prescribing of drugs for diabetes in England from 1998 to 2017
Impact of NICE guidance on tamoxifen prescribing in England 2011–2017: an interrupted time series analysis
Trends, geographical variation and factors associated with prescribing of gluten-free foods in English primary care: a cross-sectional study
OpenPrescribing: normalised data and software tool to research trends in English NHS primary care prescribing 1998–2016
New mechanism to identify cost savings in English NHS prescribing: minimising 'price per unit', a cross-sectional study
OpenPathology
Practice variation in the use of tests in UK primary care: a retrospective analysis of 16 million tests performed over 3.3 million patient years in 2015/16
Optimising laboratory monitoring of chronic conditions in primary care: a quality improvement framework
Temporal trends in use of tests in UK primary care, 2000-15: retrospective analysis of 250 million tests
Variation in diagnostic test requests and outcomes: a preliminary metric for OpenPathology.net
TrialsTracker
Compliance with legal requirement to report clinical trial results on ClinicalTrials.gov: a cohort study
Compliance with requirement to report results on the EU Clinical Trials Register: cohort study and web resource.
Prevalence of clinical trial status discrepancies: A cross-sectional study of 10,492 trials registered on both ClinicalTrials.gov and the European Union Clinical Trials Register.
The TrialsTracker: Automated ongoing monitoring of failure to share clinical trial results by all major companies and research institutions.
OpenTrials: towards a collaborative open database of all available information on all clinical trials
Policy Insights
Impact of Electronic Health Record Interface Design on Unsafe Prescribing of Ciclosporin, Tacrolimus, and Diltiazem: Cohort Study in English National Health Service Primary Care
Compliance with legal requirement to report clinical trial results on ClinicalTrials.gov: a cohort study
[PRE-PRINT] FDAAA TrialsTracker: A live informatics tool to monitor compliance with FDA requirements to report clinical trial results
Why did some practices not implement new antibiotic prescribing guidelines on urinary tract infection? A cohort study and survey in NHS England primary care
Noncommercial Funders' Policies on Trial Registration, Access to Summary Results, and Individual Patient Data Availability.
Impact of NICE guidance on tamoxifen prescribing in England 2011–2017: an interrupted time series analysis
A cross-sectional study of all clinicians' conflict of interest disclosures to NHS hospital employers in England 2015-2016.
Research Integrity
COMPare: a prospective cohort study correcting and monitoring 58 misreported trials in real time.
COMPare: Qualitative analysis of researchers' responses to critical correspondence on a cohort of 58 misreported trials
Noncommercial Funders' Policies on Trial Registration, Access to Summary Results, and Individual Patient Data Availability.
A cross-sectional study of all clinicians' conflict of interest disclosures to NHS hospital employers in England 2015-2016.
