OpenSAFELY

OpenSAFELY is a new secure analytics platform for electronic health records in the NHS, created to deliver urgent results during the global COVID-19 emergency. It is now successfully delivering analyses across more than 58 million patients’ full pseudonymised primary care NHS records, with more to follow shortly. All our analytic software is open for security review, scientific review, and re-use. OpenSAFELY uses a new model for enhanced security and timely access to data: we don’t transport large volumes of potentially disclosive pseudonymised patient data outside of the secure environments managed by the electronic health record software company; instead, trusted analysts can run large scale computation across near real-time pseudonymised patient records inside the data centre of the electronic health records software company. This pragmatic and secure approach allowed us to deliver our first analyses in just five weeks from project start.

Find out more about how OpenSAFELY works in this blog or read our papers and other blog posts, follow us on Twitter, or visit the website to find out more.

Latest OpenSAFELY blog posts

DMARD monitoring during the COVID-19 pandemic

We describe some of our recent work investigating the impact of the COVID-19 pandemic on DMARD safety monitoring across >24 million patients’ records in England.

Read more about DMARD monitoring during the COVID-19 pandemic

OpenSAFELY research software advocate vacancy

We’re hiring a research software advocate and we think you’d be a good fit

Read more about OpenSAFELY research software advocate vacancy

OpenSAFELY software engineering vacancies

We’re hiring software people and we’d love you to join us

Read more about OpenSAFELY software engineering vacancies

Latest OpenSAFELY papers

  1. Incidence and treatment of group A streptococcal infections during covid-19 pandemic and 2022 outbreak

    Investigation of the effect of the covid-19 pandemic on the number of patients with group A streptococcal infections and related antibiotic prescriptions

    Status: Published

    Categories

    • OpenSAFELY
  2. OpenSAFELY: Effectiveness of COVID-19 vaccination in children and adolescents

    We conducted a matched sequential trials observational study to assess the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination in children and adolescents in England.

    Status: Preprint

    Categories

    • OpenSAFELY
  3. Clinical coding of long COVID in primary care 2020–2023 in a cohort of 19 million adults

    Incidence and differences in demographic and clinical characteristics in recorded long COVID in primary care records in England.

    Status: Published

    Categories

    • OpenSAFELY
  4. Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations

    To examine the impact of the pandemic on deprivation-related inequalities in hospitalisations for CVD conditions in Denmark and England between March 2018 and December 2021.

    Status: Preprint

    Categories

    • OpenSAFELY