OpenSAFELY is a new secure analytics platform for electronic health records in the NHS, created to deliver urgent results during the global COVID-19 emergency. It is now successfully delivering analyses across more than 58 million patients’ full pseudonymised primary care NHS records, with more to follow shortly. All our analytic software is open for security review, scientific review, and re-use. OpenSAFELY uses a new model for enhanced security and timely access to data: we don’t transport large volumes of potentially disclosive pseudonymised patient data outside of the secure environments managed by the electronic health record software company; instead, trusted analysts can run large scale computation across near real-time pseudonymised patient records inside the data centre of the electronic health records software company. This pragmatic and secure approach allowed us to deliver our first analyses in just five weeks from project start.

Find out more about how OpenSAFELY works in this blog or read our papers and other blog posts, follow us on Twitter, or visit the website to find out more.

Latest blog posts

Latest papers

  1. Comparative safety and effectiveness of Pfizer BA.4-5 versus Sanofi during the spring 2023 COVID-19 booster vaccination programme in England: a matched cohort study in OpenSAFELY-TPP

    A comparison of the Pfizer BA.4-5 and Sanofi vaccines for protecting against Covid-19 during Spring 2023 booster programme in England

    Status
    Preprint

    Categories

    • OpenSAFELY
  1. Changes in opioid prescribing during the COVID-19 pandemic in England: cohort study of 20 million patients in OpenSAFELY-TPP

    This study described changes in prevalent and new opioid prescribing during the COVID-19 pandemic, overall, among people in care homes, and stratified by demographics.

    Status
    Preprint

    Categories

    • OpenSAFELY
  1. OpenSAFELY: Measuring BMI in 22 million patients in England

    This study describes the use of four derivations of BMI in OpenSAFELY.

    Categories

    • OpenSAFELY
  1. OpenSAFELY: a platform for analysing electronic health records designed for reproducible research

    This paper describes OpenSAFELY's reproducibility-by-design approach in detail.

    Status
    Preprint

    Categories

    • OpenSAFELY