Brian MacKenna
Director of NHS Service Analytics
Brian is Director of NHS Service Analytics at the Bennett Institute. He also works for NHS England as a pharmacist adviser and primary care medicines data clinical lead. Brian was previously Clinical Fellow to the English Chief Pharmaceutical Officer, Dr. Keith Ridge, and Deputy Head of Medicines Optimisation at Islington Clinical Commissioning Group. Brian previously worked in a variety of hospitals, in London and Australia. He has also completed his Masters in Public Health at King’s College and has a specialist interest in pharmacomedy.
Papers by Brian MacKenna
- Opioid prescribing to people on orthopaedic waiting lists during the COVID-19 pandemic in England: a study using OpenSAFELY-TPP
- Uptake of service specific codes for the COVID oximetry @Home Pulse Oximetry service: an analysis of 57 million patients' primary care records using OpenSAFELY
- Using Laboratory Test Results for Surveillance During a New Outbreak of Acute Hepatitis in 3-Week- to 5-Year-Old Children in the United Kingdom, the Netherlands, Ireland, and Curaçao: Observational Cohort Study
- Primary care coding activity related to the use of online consultation systems or remote consulting
- Impact of COVID-19 on recorded blood pressure screening and hypertension management in England
- Therapeutics Dataset from COVID-19 Medicine Delivery Units in England
- The safety of antivirals and neutralising monoclonal antibodies used in prehospital treatment of Covid-19
- Consistency, completeness and external validity of ethnicity recording in NHS primary care records: a cohort study in 25 million patients’ records at source using OpenSAFELY
- Changes in sick notes associated with COVID-19 from 2020 to 2022: a cohort study in 24 million primary care patients in OpenSAFELY-TPP
- Effectiveness of mRNA COVID-19 Vaccines as First Booster Doses in England
- Changes in opioid prescribing during the COVID-19 pandemic in England
- Trends in weight gain recorded in English primary care before and during the Coronavirus-19 pandemic: An observational cohort study using the OpenSAFELY platform
- Healthcare utilisation in people with long COVID
- Exploring Prior Antibiotic Exposure Characteristics for COVID-19 Hospital Admission Patients
- Data-Driven Identification of Potentially Successful Intervention Implementations Using 5 Years of Opioid Prescribing Data
- Incidence and treatment of group A streptococcal infections during covid-19 pandemic and 2022 outbreak
- OpenSAFELY: Effectiveness of COVID-19 vaccination in children and adolescents
- Clinical coding of long COVID in primary care 2020–2023 in a cohort of 19 million adults
- Impacts of the COVID-19 pandemic on deprivation-level differences in cardiovascular hospitalisations
- Impact of the COVID-19 pandemic on antidepressant prescribing with a focus on people with learning disability and autism: an interrupted time series analysis in England using OpenSAFELY-TPP
- Impact of long COVID on health-related quality-of-life: an OpenSAFELY population cohort study using patient-reported outcome measures (OpenPROMPT)
- Identification of patients undergoing chronic kidney replacement therapy in primary and secondary care data
- The impact of COVID-19 on azathioprine, leflunomide and methotrexate monitoring, and factors associated with change in monitoring rate
- The impact of COVID-19 on medication reviews in English primary care
- Comparative safety and effectiveness of Pfizer BA.4-5 versus Sanofi during the spring 2023 COVID-19 booster vaccination programme in England
- During the COVID-19 pandemic 20 000 prostate cancer diagnoses were missed in England
- Measuring BMI in 22 million patients in England
- Weight trends amongst adults with diabetes or hypertension during the COVID-19 pandemic
- Safety of direct-acting oral anticoagulant (DOAC) prescribing
- OpenSAFELY: a platform for analysing electronic health records designed for reproducible research
- Trends in inequalities in avoidable hospitalisations across the COVID-19 pandemic
- Educational interventions delivered to prescribing advisers to influence primary care prescribing: a very low-cost pragmatic randomised trial using routine data from OpenPrescribing.net
- Clinical and health inequality risk factors for non-COVID-related sepsis during the global COVID-19 pandemic
- Interpreting pathology test result values with comparators (<, >) in Electronic Health Records research
- Antibiotics for Common Infections in Primary Care Before, During and after the COVID-19 Pandemic and Extent of Risk-Based Prescribing: Need for Personalised Guidelines
- The impact of the COVID-19 pandemic on the treatment of common infections in primary care and the change to antibiotic prescribing in England
- Impact of the COVID-19 pandemic on antipsychotic prescribing in individuals with autism, dementia, learning disability, serious mental illness or living in a care home
- Gout incidence and management during the COVID-19 pandemic in England, UK
- Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway
- Eleven key measures for monitoring general practice clinical activity during COVID-19
- Evaluation of the impact of COVID-19 pandemic on hospital admission related to common infections
- Repeated antibiotic exposure and risk of hospitalisation and death following COVID-19 infection
- Ethnic differences in the indirect effects of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England
- Patient Characteristics Associated with Repeat Antibiotic Prescribing Pre- and during the COVID-19 Pandemic
- A National Audit of Pancreatic Enzyme Prescribing in Pancreatic Cancer from 2015 to 2023 in England
- Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY
- Effectiveness of Sotrovimab and Molnupiravir in community settings in England across the Omicron BA.1 and BA.2 sublineages
- Impact of COVID-19 on broad-spectrum antibiotic prescribing for common infections in primary care in England
- The impact of COVID-19 on antibiotic prescribing in primary care in England
- Challenges in Estimating the Effectiveness of COVID-19 Vaccination Using Observational Data
- Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022
- Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England
- Comparative effectiveness of BNT162b2 versus mRNA-1273 covid-19 vaccine boosting in England
- First dose COVID-19 vaccine coverage amongst adolescents and children in England
- Trends, variation, and clinical characteristics of recipients of antiviral drugs and neutralising monoclonal antibodies for covid-19 in community settings
- OpenSAFELY NHS Service Restoration Observatory 2
- Identifying Patterns of Clinical Interest in Clinicians' Treatment Preferences: Hypothesis-free Data Science Approach to Prioritizing Prescribing Outliers for Clinical Review
- Comparative effectiveness of two- and three-dose schedules involving AZD1222 and BNT162b2 in people with kidney disease
- Comparative effectiveness of sotrovimab and molnupiravir for prevention of severe covid-19 outcomes in patients in the community
- Incidence and management of inflammatory arthritis in England before and during the COVID-19 pandemic
- Recording of ‘COVID-19 vaccine declined’
- Association between household composition and severe COVID-19 outcomes in older people by ethnicity
- Waning effectiveness of BNT162b2 and ChAdOx1 covid-19 vaccines over six months since second dose
- Comparative effectiveness of ChAdOx1 versus BNT162b2 COVID-19 vaccines in Health and Social Care workers in England
- Representativeness of electronic health record platform OpenSAFELY-TPP data compared to the population of England
- Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England
- Association between oral anticoagulants and COVID-19-related outcomes
- Risk of severe COVID-19 outcomes associated with immune-mediated inflammatory diseases and immune modifying therapies
- Safety of COVID-19 vaccination and acute neurological events
- Impact of First UK COVID-19 Lockdown on Hospital Admissions
- Accident and emergency (AE) attendance in England following infection with SARS-CoV-2 Omicron or Delta
- Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19 in England
- Comparison of methods for predicting COVID-19-related death in the general population using the OpenSAFELY platform
- Potentially inappropriate prescribing of DOACs to people with mechanical heart valves
- Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation
- Mortality among Care Home Residents in England during the first and second waves of the COVID-19 pandemic
- OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19
- Trends and clinical characteristics of COVID-19 vaccine recipients
- Impact of national guidance on switching anticoagulant therapy during COVID-19 pandemic
- Clinical coding of long COVID in English primary care
- Association between warfarin and COVID-19-related outcomes compared with direct oral anticoagulants
- Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England
- Risks of covid-19 hospital admission and death for people with learning disability
- Factors associated with deaths due to COVID-19 versus other causes
- Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England
- Identifying Care Home Residents in Electronic Health Records
- Association between living with children and outcomes from covid-19
- Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7
- Changes in the rate of cardiometabolic and pulmonary events during the COVID-19 pandemic
- Short report: Ethnicity and COVID-19 death in the early part of the COVID-19 second wave in England
- Use of non-steroidal anti-inflammatory drugs and risk of death from COVID-19
- HIV infection and COVID-19 death
- Effect of pre-exposure use of hydroxychloroquine on COVID-19 mortality
- Impact of Electronic Health Record Interface Design on Unsafe Prescribing of Ciclosporin, Tacrolimus, and Diltiazem: Cohort Study in English National Health Service Primary Care
- Comparison of different risk prediction modelling approaches for COVID-19 related death using the OpenSAFELY platform
- Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids
- Suboptimal prescribing behaviour associated with clinical software design features: a retrospective cohort study in English NHS primary care
- Prescription of suboptimal statin treatment regimens: a retrospective cohort study of trends and variation in English primary care
- The NHS deserves better use of hospital medicines data
- Factors associated with COVID-19-related death using OpenSAFELY
- Trends and variation in unsafe prescribing of methotrexate: a cohort study in English NHS primary care.
- Six months on – NHS England needs to focus on dissemination, implementation and audit of its Low-Priority Initiative